Temovate (Clobetasol Propionate)

Temovate Review

Temovate cream is a topical anti-inflammatory medication that helps reduce itching, redness, and swelling associated with many skin conditions. Temovate cream is safe for virtually every skin type, and produces very little side effects.

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Temovate Drug Class and Mechanism

Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Temovate Uses

TEMOVATE Cream and Ointment are super-high potency corticosteroid formulations indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g/week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Use in pediatric patients under 12 years of age is not recommended.

Temovate Side Effects

Acneform eruptions
Allergic contact dermatitis
Burning sensation
Cracking and fissuring
Cushing's syndrome
Dryness
Erythema
Folliculitis
Hypertrichosis
Hypopigmentation
Itching
Irritation
Millaria
Numbness of fingers
Perioral dermatitis
Pruritus
Secondary infection
Skin atrophy
Skin maceration
Stinging
Striae
Telangiectasia

Temovate Pregnancy

Temovate Overdose

Topically applied TEMOVATE Cream and Ointment can be absorbed in sufficient amounts to produce systemic effects

Temovate More Information

Do not use plastic bandages, dressings, or diapers that do not allow air to circulate to the area unless your doctor directs you to do so. The use of occlusive dressings can greatly increase the amount of drug the body absorbs. If you do use an occlusive dressing, do not use it for more than 12 hours a day. Do not use other topical products on the treated area, unless otherwise directed by your doctor.